SET-C : two studies detail the new disease linked to the Covid-19 affecting children

The disease has been confirmed to be very rare and usually occurs within weeks of infection with the SARS-CoV-2 virus. Two US studies published Monday show

The disease has been confirmed to be very rare and usually occurs a few weeks after infection with the SARS-CoV-2 virus.

Two US studies published Monday provide a more documented description than ever before of the symptoms of a mysterious coronavirus-related illness that has affected at least 1,000 children worldwide, called multisystem inflammatory syndrome in children (C-SET).

Both studies, published in the New England Journal of Medicine, are based on nearly 300 children and young people under 21 who had (or strongly suspected) Covid-19, identified in the United States between March and May, following an alert launched in Britain in late April, and then by the US Centers for Disease Control and Prevention (CDC) in May.

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A thousand cases have been reported worldwide, including these new studies, Michael Levin of Imperial College London said in an editorial published by NEJM. On May 15, the European Center for Disease Prevention and Control reported 230 cases in Europe, including two deaths in France and the United Kingdom.

“Very rare” disease

As we suspected, it is clear that the syndrome appears a second time, a few weeks after infection by the SARS-CoV-2 virus: a national study reports a median duration of 25 days, while another, in New York, indicates that most cases occurred one month after the peak of the pandemic in the city.

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It has been confirmed that the disease is very rare: 2 cases per 100,000 people under 21 years of age. As doctors on both sides of the Atlantic have noted, children of black, Hispanic, or Native American descent are relatively more affected than white children.

gastrointestinal disorders

The most common symptom is shortness of breath: more than 80% of the children had, namely gastrointestinal disorders (abdominal pain, nausea or vomiting, diarrhea), and many had skin rashes, especially under five years of age. They all had a fever, very often for more than four or five days. And in 80% of them it was the cardiovascular system. From 8% to 9% of children have a developed aneurysm of the coronary arteries.

most of the children were previously healthy and had no risk factors or pre-existing disease. 80% were admitted to the intensive care unit, 20% received invasive respiratory support, and 2% died.

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At the time of the first report, doctors noted many similarities to Kawasaki disease, which mainly affects infants and very young children and causes inflammation of the blood vessels that can lead to heart problems. These new data confirm that MIS-C and Kawasaki have points of contact, but that the new syndrome usually affects older children and causes more intense inflammation.

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The cause of the syndrome, which is suspected to be related to an abnormal immune system response, remains a mystery. This could have implications for vaccine development and inflammation that has also been seen in multiple organs in adult covid-19 patients, suggests Michael Levin.

Update date: July 1, 2020, 05:58

Categories: Optical Illusion
Source: newstars.edu.vn

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